by maipham

June 8, 2020

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Are you breastfeeding your baby? Or are you going formula?

Whatever you decide, it’s ok. At the end of the day, fed is best. The only thing that matters is that your baby is well-fed. Period.

If formula is your choice, then you can easily get confused with all the choices out there. When I was searching the formula for Ethan, I was like, “heck, I don’t know which one to go for”. How do you know which one is the best? How do you know which one suits your baby?

Some moms, including myself, have the luxury of switching back and forth between different formulas. But for other moms, they can’t afford to do so because of their babies’ over-sensitive stomachs.

While there are plenty of formula choices out there, the question that I’ve been asked the most is, what is the difference between Similac Pro Advance and Advance? In this article, we are going to find out everything we need to know about these two, and the differences between them.


The main difference between Similac Pro Advance and Advance

The main thing that distinguishes these two is that Similac Pro Advance has 2’-FL HMO, which is a unique immune-nourishing prebiotic.

Well, I personally don’t understand all the capitals and short words. So exactly, what does 2’-FL HMO do to your baby?

According to Wikipedia, it is the most prevalent human milk oligosaccharide naturally present in human milk. It helps strengthen the immune system. According to Abbott’s research, babies who drink formula with 2’-FL HMO have the same immune system to babies who are breastfed.

Similac Pro Advance and Advance comparison table

Similac Advance

Similac Pro Advance

  • Treated with r-BST
  • 2’FL Human Milk Oligosaccharide (HMO) is absent
  • Made with GMO ingredients
  • Contains OptiGRO ingredients
  • Side effects such as spitting up, gas etc. are mitigated.
  • Not treated rBST cow’s milk
  • 2’FL Human Milk Oligosaccharide (HMO) is present
  • Made with non-GMO ingredients
  • Contains OptiGRO ingredients
  • Side effects such as spitting up, gas etc. are mitigated.

Similac Pro Advance reviews – best for who?

This is a formula used for infants as a replacement for breast milk. It is designed to meet the infant’s mommy’s breast milk needs as much as possible.

Similac Pro Advanced is among the best formulas as it is engineered towards emulating the characteristics of real breast milk, even if it comes in powdered form, it is dense enough to pass breast milk to an infant.

If you are unable to breastfeed your baby but still want to provide your baby with the formula that is closest to breast milk, this formula might be your perfect answer. However, it is quite pricey, and it can be hard to keep up if you are under a tight budget.

Similac Advance reviews – best for who?

Although it doesn’t contain 2’FL HMO, Similac Advance still consists of all the needed ingredients for infants and babies. While there is no visible different effectiveness between Similac Pro Advance and Similac Advance, if you are under a tight budget, Similac Advance is a great option.

Especially if you are half breastfeeding your baby, and use formula as a supplement, you don’t have to worry so much about which type to go for. In this case, Similac Advance is enough to provide your baby with everything he needs for his earliest day.

Smell and taste

Because of the more advanced formula of Similac Pro Advance, it has a sharper smell, although even that’s not too noticeable, so it will not bother your infant. Similac Advance has a tin like smell that may bother babies with a very sensitive nose.

Regarding the taste, Similac Advance has a more baby-friendly taste. If your baby is used to breastmilk or is introduced with Similac Advance since his earlier days, he might refuse the Similac Pro Advance due to its stronger taste.

My son Ethan didn’t seem to have any problem with it though. We were able to switch back and forth between several formulas and he enjoyed them all.

Impact on the tummy

Some parents say that the Similac Pro Advance reduces spit-up, vomiting, and gas in infants without causing any significant allergies.

Similac Advance, on the other hand, contains ingredients that are also effective for all these. However, it has been found to trigger mild allergies in infants that are too sensitive and prone to allergies.


For the nutrients, Similac Pro Advance provides more benefits to your baby. However, if you are under a budget, Similac Advance is also a great option.

Don’t stress yourself over a fancy formula. Remember, your baby has his whole life ahead to eat healthy. You will be better off spending your energy to relax and enjoy your life with him, rather than getting all stressed out about money and formula.

About the author 

Mai Pham

Mai Pham discovered her passion for writing a few years ago and she never stop thinking about it ever since. She finally took the leap and created Live a Worthy Life to brag about her smart ass (mainly just for fun). Enjoyed the fun writing brings, now with her new interest in everything-baby-related, she created Mommy Instinct, to tell mamas that it's ok that they mess up, that they don't know what the hell they are doing, and that it's okay to sit back and relax for a while.

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